We are seeking a passionate and talented Postdoctoral Researcherto advance the field ofapplied machine learning in the context of human genetic data. This individual will conceive and execute analyses clarifying the application of natural language processing models to diverse aspects of early biological target discovery and evaluation while embedded within a collaborative academic/biotech setting. Using large-scale transformer neural networks to model the effects of protein coding variation in the human genome, the successful candidate will lead the development of novel methodology to characterize disease relevance and lay the foundations for an ultra-high throughput experimental framework
This position is supported by the Maze Advanced Analytics Fellowship Program, which provides funding and scientific engagement to scholars interested in applied research bridging academic and industrial applications. The candidate will be jointly supervised by Dr. Vasilis Ntranos at UCSF and the Data Sciences group at Maze Therapeutics, and will work as part of a cross-functional team comprised of Data Scientists, Functional Genomic Scientists, Human Geneticists, and Computational Chemists to facilitate highly multidisciplinary early discovery research.
D. in Human Genetics, Bioinformatics, Computer Science, or similar disciplines
Strong critical thinking, experimental design, programming, and data analysis skills
Knowledge of key Human Genetics concepts and outstanding biological questions amenable to machine learning approaches
Familiarity with basic machine learning workflows and computational modeling applications is required; experience with modern neural network preferred
Familiarity with state-of-the-art machine learning approaches applied to biological sequence data (e.g., in the context of protein prediction tasks) is strongly preferred
Enthusiasm for cross-functional collaboration in a highly multidisciplinary intellectual environment
Excellent communication, presentation, collaboration, and organizational skills
Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing the power of human genetics to transform the lives of patients through the development of a pipeline of novel precision medicines for patients with genetically defined diseases. Maze is leveraging Compass™, a proprietary, end-to-end purpose-built platform to advance a pipeline of precision medicines across four disease areas - renal, cardiac, neurological and metabolic diseases. Our flexible business model aims to translate our genetic insights into as many new therapies for patients as possible. Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.